Assistant Professor, Department of Internal Medicine
Bio
Dr. Marzo is a breast cancer researcher at Rush University Medical Center whose work focuses on overcoming resistance to immunotherapy in triple-negative breast cancer. Her research investigates how to manipulate the immune system to effectively eradicate tumors that do not respond to current treatments and to identify cellular and molecular signatures that predict therapeutic response. Driven by lifelong curiosity and a personal passion for science, she develops innovative strategies to enhance anti-tumor immunity. Beyond her laboratory work, Dr. Marzo is committed to translating her findings into clinical approaches that could improve outcomes for patients with hard-to-treat breast cancers.
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that often fails to respond to conventional therapies, including promising immunotherapies like anti-PD1 treatment. This study aims to understand why TNBC tumors develop resistance to these therapies and to use new combination therapies that enhance the immune system’s ability to eliminate both primary and metastatic tumors. By identifying cellular and molecular signatures of therapeutic response and resistance, this research seeks to predict patient responses and develop new pre-clinical regimens that could be translated into clinical trials, offering a path toward more effective treatments for this difficult-to-treat cancer.
Amanda L. Marzo, PhD
Rush University Medical Center
Current
Senior Investigator
Dezheng Huo, PhD
Using Artificial Intelligence to Integrate Imaging and Genetic Markers for Personalized Breast Cancer Risk Prediction
Current
Senior Investigator
Seema Khan, MD
Optimizing Family Planning for Young Women at High Risk of Breast Cancer
Why your gift matters
Your gift helps researchers test bold ideas, generate critical data, and take the first steps toward the next major advancement in breast cancer treatment and care.Together, we can accelerate discoveries that save lives.
